➜  ~ wine64 /home/jbo/downloads/Factorio_2.0.43/bin/x64/factorio.exe
/home/jbo/.i386-wine-pkg//usr/local/bin/wine doesn't exist!

Try installing 32-bit Wine with
	/usr/local/share/wine/pkg32.sh install wine-devel mesa-dri

If using Poudriere, please make sure your repo is setup to use FreeBSD:14:i386
and create symlinks for
  FreeBSD:14:amd64 and
  FreeBSD:14:i386
to the relevant output directories. See pkg.conf(5) for more info.